The first nine episodes focus on Annalise’s defense of Caleb and Catherine Hapstall, who were accused of torturing and murdering their adoptive parents. Wes, in the meantime, teams up with Rebecca’s foster brother to try and find Rebecca. Connor struggles with his relationship with Oliver, while Asher works with A.D.A. Emily Sinclair, in order to protect his secrets. In the mid-season finale, Sinclair is murdered, and Annalise helps cover it up, at the expense of her being shot in the stomach by Wes.

The second part of the season focuses on Wes’s investigation of his mother’s suicide ten years earlier; flashbacks reveal Annalise’s involvement with Wes’s mother’s suicide. The season ends with Annalise’s finding out that Frank was responsible for the car crash that killed her baby, and Annalise sending him away. Michaela and Asher hook up, and Wes meets with his biological father right before the latter is shot dead by an unknown shooter.